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Amphiphilic p-tert-butylthiacalix[4]arenes containing quaternary ammonium groups: From small molecules toward water-soluble nanoscale associates

Дата публикации: 2015-01-01

Дата публикации в реестре: 2018-11-30T10:45:53Z

Аннотация:

Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd. The formation of supramolecular associates based on water-soluble p-tert-butylthiacalix[4]arenes with amino acids has been studied. It was shown that amphiphilic p-tert-butylthiacalix[4]arenes preferably formed supramolecular associates with aromatic α-amino acids (tyrosine and tryptophan). Increasing size of the substituents of p-tert-butylthiacalix[4]arenes led to increase molecular weight of supramolecular associates based on the macrocycles and "guest" molecules. The spatial structures of p-tert-butylthiacalix[4]arenes and their associates with phenylalanine were studied by two-dimensional 1H-1H nuclear Overhauser effect NMR spectroscopy. The ability of aggregates based on p-tert-butylthiacalix[4]arenes and amino acids to effectively interact with bovine serum albumin with the formation of 7- to 8-nm nanoparticles was shown.

Тип: Article